Obesity

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Independently of diet and exercise low testosterone plays a determinant role in obesity

2012:Testosterone as Potential Effective Therapy in Treatment of Obesity inMen with Testosterone Deficiency: A Review. Download pdf (7)

Monitoring of androgens is essential to define hormonal deficiencies.

History of andropause disease

Accumulation of fat leads to overweigth and obesity .

Glass and coll. from the department of medicine from the UCLA School of Medicine in California reported, in 1976, that plasmatic testosterone levels are decreased in obese men (1-2-3-4-5).

LOW PLASMA TESTOSTERONE IN MASSIVELY OBESE MEN
	Plasma Testosterone in nanograms/100 ml.
Obese group (200 to 280 % of the ideal body weight)	223
Control group (85 to 135 % of the ideal body weight)	599

According to Glass and coll.

In 1990, Zumoff and coll. from the division of Endocrinology and Metabolism from the Beth Israel Medical Centre in New York, reported that free and total testosterone levels are clearly subnormal in obese men. The degree of subnormality is proportional to the degree of obesity and the authors conclude : "Hormonally speaking, the distinction between morbid obesity and lesser degrees of obesity would seem to have no validity; the decline of free, non-SHBG-bound, and total testosterone levels in obese men represents a continuum, observable at any degree of obesity" (6).

Because the decrease of testosterone secretion with age is seems logical to believe that this phenomenon is a leading cause of fat deposits everywhere in the body and that overweight is a clinical sign of andropause.

2012 : Testosterone as Potential Effective Therapy in Treatment of Obesity in Men with Testosterone Deficiency: A Review. Download pdf (7).

TRANSFORMATION OF THE SILHOUETTE

The silhouette of the climacteric men is often typical, with overweight and abdominal ballooning, consequence of the weakness of the bowel's muscles. An increase of male hormones is also responsible for breast enlargement which is very common in old men .

The regressive man's silhouette

The progressive man's silhouette

Bibliography

1. LIPID RESEARCH PROGRAM -The Lipid Research Clinics Population Studies Data Book -NIH Publication No 80 : 1527, vol 1 BETHESDA, 1980.

2. CREFF A.F. AND HERCHBERG A.D. Obésité, p.126. Masson. 1988

3. Marks H.H. -Influence of Obesity on Morbidity and Mortality : Bull. N.Y. Acad. Sc., 36 : 296, 1960.

4. RAISON J. Obésité Androïde : le Mécanisme de la Surmortalité Cardio-Vasculaire est Expliqué : Le Quotidien du médecin, 4632 :14-15, 1990.

5. GLASS A.R., SWERDLOFF R.S., BRAY G.A., DAHMS W.T., ATKINSON R.L. Low Serum Testosterone and Sex-Hormone-Binding-Globulin in Massively Obese Men : J. Clin. Endocrinol. Metabol., 45,6 : 1211-1219, 1977.

6. ZUMOFF B., STRAIN G.W., MILLER L.K., ROSNER W., SENIE R., SERES D.S. AND ROSENFELD R.S. Plasma Free and

Non-Sex-Binding-Globulin-Bound Testosterone Are Decreased in Obese Men in Proportion to their Degree of Obesity : J. Clin. Endocrinol. Metabol., 71,4 : 929-931, 1990.

7. Farid Saad, Antonio Aversa, Andrea M. Isidori, Louis J. Gooren. Testosterone as Potential Effective Therapy in Treatment of Obesity in Men with Testosterone Deficiency: A Review. Current Diabetes Reviews, 8, 131-143, 2012.