Since years PSA test is
used as a specific marker of prostate cancer (when
PSA also increases in adenoma or infection of
the prostate).
PSA tests are also made
to follow the treatments' responses.
The global mortality
of prostate cancer has not been modified
significantly since the beginning of twenty
century.
In
the USA they are insurers who do not refund any
more detection of PSA tests for preventive
diagnosis of the cancer of the prostate.
Notwithstanding, it
would be interesting to know PSA levels in each
person at any age because the first stages of cell's
transformations and increase of PSA level can be
reversed with appropriate
therapy with androgens(exhaustive studies are
necessary).
Many doctors have
been slow to recognize that the use of PSA for
screening lacks sensitivity and specificity, and
cannot distinguish an aggressive from nonaggressive cancer, thereby leading to
over-diagnosis and over-treatment (Richard J
Ablin).
Download,pdf.
Error
1:
PSA is not specific
to prostate
cancer. It is an activity's marker
which level in the blood varies between 1 and 4
Nanograms/ml.
A simple prostate
infection can elevate PSA levels. A prostate
adenoma may also regress
(prostate volume and PSA) with
an appropriate therapy with androgens.
Error 2 :
To believe that
testosterone provokes cancerous prostate
transformation ignoring the different grades of
prostate cells.
They are
ten grades to evaluate prostate cancer
known as " Gleason's grades" :
The 5 or 6 first
grades of transformation can regress under the
influence of male hormones
Download pdf.
Aggressive grades
can be stimulated to higher degrees under male
hormones-Download pdf.
MORPHOLOGICAL RESPONSES OF PROSTATIC
CARCINOMA TO TESTOSTERONE IN ORGAN CULTURE.
Androgens
must be avoided If PSA
level rises under androgens' therapy.
Error 3 :
To misunderstand the
balance between testosterone and
dihydrotestosterone on prostate cells.
Fatal Error 4
:
Misunderstanding
errors 1 to 3 and ignoring personalized therapy
and companion diagnostics in each patient
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